The major tweaks and differences between reference cards and various manufacturers is the RAM size, RAM clock, gpu clock, and cooling. Essentially, you get an overclocked card that is guaranteed to work at that speed for the price of a standard model. If a reputable vendor pushes a card to a higher speed than another, it's usually because they have determined a safe way to do so. Enthusiasts pay close attention to what they are able to do, and they publish their findings in hardware forums like overclockers.com, 3dguru.com, anandtech.com and others. My experience tells me Sapphire, XFX, eVGA, Palit, and BFG Tech are good vendors. Very rarely will you only see one vendor with a top performing card, since there's only so much they can improve on the reference design.