You could be facing database corruption.
When this happens again try the following:
* Stop the Data Protector Service
* Edit HP\Data Protector Express\config\dpconfig.ini
* In the [configuration] section add the line repairDatabase=Yes
* Start up the GUI, without starting the service
* You will see it will perform several passes on the database (trying to repair it).
* If the repair ends, start the service again and check if your problem is solved.
If it's still not solved, try the following:
* Stop the service
* Rename the HP\Data Protector Express\database directory.
* Start the service - try opening the GUI again.
If that works, you'll now have an empty database. If you made a backup of the database (by selecting the Storage Domain in one of the Data Protector Jobs) then this is the time to restore it to the time it was not corrupt.