seeing they will be running on two separate interfaces, you're more likely to be free from running into any issues than if you were to use 2 PCI cards, i'd say. although, I would stick with the same brand - so if I were you, i'd go with a similar nVidia card.
i suppose if you wanted a "for sure" answer on whether the video card you have now and the one you are looking to purchase are compatible, you would need to do some research on the card you're looking to buy, perhaps calling the company to verify.